A question being hotly debated by countries is whether ‘Digital Sequence Information’ (DSI) should be included within scope of the CBD and Nagoya Protocol. This includes DNA sequence data downloadable from public databases, and therefore is of major interest to taxonomists. Inclusion within the CBD could have a major impact on taxonomic work.
Access and utilisation of physical genetic resources – plants, animals and microorganisms – are covered by the Nagoya Protocol. However, it is now possible to download DNA sequences from public databases and reconstruct the DNA then use it as one might a gene extracted directly from an organism. In the view of many provider countries, this provides a loophole for commercial exploitation, since there is no need for a user to seek any type of permit or agree terms for benefit sharing.
Currently many countries, including UK understand that 'DSI' downloaded from public databases is not covered by the Nagoya Protocol. However, some countries believe strongly that it should be or even is covered by the Protocol. For this reason they are making a strong case to include it in the CBD (as well as the International Treaty for Plant Genetic Resources for Food and Agriculture, and the developing instrument for Biodiversity Beyond National Jurisdiction). If it is eventually decided that DSI comes under the CBD and Nagoya Protocol, it could lead to benefit-sharing requirements and increased complexity of access to resources such as GenBank, as well as monitoring by national authorities.
Moreover, some countries, such as Brazil, have included DSI in their domestic Access legislation clauses even if the DSI is held outside their borders.
All of this has led to current legal uncertainty of our work with some countries, and a threat to open access of data.
What is DSI?
While the term ‘Digital Sequence Information’ is used in CBD discussions, it is undefined and interpreted differently by different stakeholders, with its scope ranging from nucleotide sequence data to protein composition to the chemistry of cell metabolites, and at the extreme all information including contextual information about the genetic resource. Several attempts have been made to clarify the scope, and many submissions made to the CBD by stakeholders, including the NHM, RBG Kew and RBG Edinburgh (links given below).
Key documents include:
Report of the 2018 CBD Ad Hoc Technical Expert Group on DSI (AHTEG) (see here)
A study in Concept and Scope commissioned by the CBD in 2019 is on the CBD web site here.
A Combined study on digital sequence information in public and private databases and traceability commissioned by the CBD in 2019 which is available here.
Report of the 2020 CBD AHTEG (see here). This report will be considered by the CBD group discussing the Post-2020 Global Biodiversity Framework, which will then report to COP 15 in China, when this takes place.
What countries regulate DSI, and how?
An increasing number of countries include DSI in some concept in their domestic legislation. This may impact how taxonomists use the data. The CBD commissioned a report on Domestic legislation, which can be found here.
Engagement by NHM, Kew and Edinburgh
This area is being considered by ABS experts in NHM, RBG Kew, CETAF and GGBN, who are keeping a watching brief on developments, sending represnetatives to relevant meetings and workshops, and advising where appropriate. We made submissions to Defra and the CBD on the subject in 2017 and 2019 explaing our understanding of the terminology, the significance of ‘DSI’ to conservation and sustainable use, and how benefit-sharing operates in the context of DSI. Organisations to which NHM, RBG Kew and RBG Edinburgh belong (e.g. CETAF, SPNHC, GGBN), have also made submissions to the CBD (links to submissions in next section).
The CBD has placed on its website information and documents about the discussion and negotiations, including relevant COP decisions. This can be found here
The German Federal Ministry of Education and Research (BMBF) has funded an interdisciplinary project (WiLDSI) led by the Leibniz Institute DSMZ and the Leibniz Institute IPK Gatersleben to investigate possible solutions for how to handle DSI within the CBD framework. This has produced a very helpful report, and has a very strong science and collection-based engagement. Further information can be found here.
Several presentations from Chris Lyal (NHM) may be of interest:
The use of DSI for taxonomy and other related non-commercial research on biodiversity – this can be found here.
On legal issues and definitional issues, and can be found here.
On the results of the 2020 AHTEG, which can be found here.
Presentations delivered in Webinars on DSI in late 2020 – early 2021 are available on the ABS Capacity Development Initiative DSI page
Relevant discussions are also be taking place in other fora:
- The International Treaty on Plant Genetic Resources for Food and Agriculture is considering the issue. A relevant background document can be accessed here. The IISD summary of the 16th session, which included considerable discussion on digital sequence data and proposed synergistic activities with the CBD, is available here.
- The Commission on Genetic Resources for Food and Agriculture is also considering the issue and their website is here. A report “Digital Sequence Information” on Genetic Resources for Food and Agriculture and its Relevance for Food Security is available here. An earlier fact-finding study is available here. A more recent (2021) report “Digital Sequence Information” on Genetic Resources for Food and Agriculture: Innovation Opportunities, Challenges and Implications” can be found here
- The United Nations Convention on the Law of the Sea is developing an International Instrument on Biodiversity Beyond National Jurisdiction. This will include an element on ABS relating to Marine Genetic Resources. See here
- The WHO has been discussing Genetic Sequence Data in the context of influenza virus. Information can be found here. It includes a link to a report "Optimal characteristics of an influenza genetic sequence data sharing system under the pip framework"
Many relevant reports and papers are available, of which this is only a small subset:
ABS Capacity Development Initiative, 2019, Digital Sequence Information on Genetic Resources (DSI) - An Introductory Guide for African Policymakers and Stakeholders.
ABS Capacity Development Initiative, 2020, Report - First Global Dialogue on Digital Sequence Information on Genetic Resources 6–8 November 2019, Pretoria, South Africa. Available here
Bagley, M.A., 2015, Digital DNA: The Nagoya Protocol, Intellectual Property Treaties, And Synthetic Biology. University of Virginia School of Law. Online here.
Bagley, M.A., 2017, Towering Wave or Tempest in a Teapot? Synthetic Biology, Access & Benefit Sharing, and Economic Development, in Susy Frankel and Daniel Gervais eds.THE INTERNET AND INTELLECTUAL PROPERTY: THE NEXUS WITH HUMAN AND ECONOMIC DEVELOPMENT (Victoria University Press, forthcoming 2017). Text available here.
Bagley, M.A., A.K. Rai (2013). The Nagoya Protocol and synthetic biology research: a look at the potential impacts, Wilson Center, Washington, DC. Available here.
CETAF (2018) Digital Sequence Information (DSI) of Genetic Resources. Executive Statement. Online here
Dedeurwaerdere T, P. Melindi-Ghidi, A. Broggiato (2016). “Global scientific research commons under the Nagoya Protocol: topwards a collaborative economy model for the sharing of basic research assets”, Environmental Science & Policy 55:1, 1-10. Available here
Dedeurwaerdere T., A. Broggiato, S. Louafi, E. Welch, F. Batur (2012). “Governing Global Scientific Research Commons under the Nagoya Protocol” in Morgera E., M. Buck, E. Tsioumani (eds) The Nagoya Protocol in Perspective: Implications for International Law, Martinus Nijhoff. Available here.
Garrity G.M., L.M. Thompson, D.W. Ussery, N. Paskin, D. Baker, P. Desmeth, D.E. Schindel and P.S. Ong (2009) Studies on Monitoring and Tracking Genetic resources. UNEP/CBD/WG-ABS/7/INF/2. (2013).
Hammond, E. (2016). Digital genebankers plan to ignore UN request on the impact of genomics and synthetic biology on access and benefit sharing, Third World Network, A preliminary Report, 4 April. Available here
Hammond, E., 2016. TWN briefing “Digital DNA” and Biopiracy: Protecting Benefit-Sharing as Synthetic Biology Changes Access to Genetic Resources. Available here.
Karger, E., du Plessis and Meyer, Hartmut (2019) Digital Sequence Information on Genetic Resources (DSI) - An Introductory Guide for African Policymakers and Stakeholders. ABS Capacity Development Initiative. Available here.
Lawson, C. & Rourke, M., 2016, Open Access DNA, RNA and Amino Acid Sequences: The Consequences and Solutions for the International Regulation of Access and Benefit Sharing. Available for download here. Abstract: This article addresses how open access to DNA, RNA and amino acid sequences might be reconciled with the benefit sharing obligations under the United Nations’ Convention on Biological Diversity and its Nagoya Protocol, the Food and Agriculture Organisation of the United Nations’ International Treaty on Plant Genetic Resources for Food and Agriculture and the World Health Organisation’s Pandemic Influenza Preparedness Framework for the Sharing of Influenza Viruses and Access to Vaccines and Other Benefits. Tracing the evolution of open access databases the article posits models for reconciling open access and benefit sharing, the article concludes, however, that none of the proposed solutions – monitoring and tracing, the contract model, and the copyright and database right model – provides a perfect solution. Each model does, however, suggest that open access to these sequences might be at least partially reconciled with benefit sharing.
Lyal, C.H.C. (2020)  Chapter 19: Current situation on Digital Sequence Information (DSI), pp119-124 IN Kamau, EC (ed) "Implementation of the Nagoya Protocol: Fulfilling new obligations among emerging issues." BfN-Skripten 564 pp x + 142.
Manzanella, D. 2016, The Global Information System And Genomic Information: Transparency Of Rights And Obligations. Background paper commissioned by the International Treaty on Plant Genetic Resources for Food and Agriculture (click on title to open).
Muller, M.R., 2015, Genetic Resources as Natural Information: Implications for the Convention on Biological Diversity and Nagoya Protocol. Routledge. 170pp. Available here.
Oldham, P. (2020) Digital Sequence Information -Technical Aspects.
Reichman, J.H., Paul F. Uhlir, P.F. & Dedeurwaerdere, T., 2016, Governing Digitally Integrated Genetic Resources, Data and Literature: Global Intellectual Property Strategies for a Redesigned Microbial Research Commons. (Cambridge U. Press) Information on how to obtain the book here. [NB There is an option to read a pre-publication version; whever I have tried to access it my browser has frozen]
Scholtz et al., (2020) “Finding Compromise on ABS & DSI in the CBD: Requirements & Policy Ideas from a Scientific Perspective”. doi: 10.13140/RG.2.2.35180.80001. available here
Servick, K., 2016, Rise of digital DNA raises biopiracy fears. Science DOI: 10.1126/science.aal0395 Online here
Smyth, S.J., Macall, D.M., Phillips, P.W.B. and de Beer, J. (2018) Governance of Digital Sequence Information and Impacts for Access and Benefit Sharing. A report prepared by: Centre for the Study of Science and Innovation Policy Johnson Shoyama Graduate School of Public Policy University of Saskatchewan. 24pp. Available here